Blar i forfatter "Islam, Md Ashraful"

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    • Biology of mesenchymal stromal cells: Chondrogenesis, paracrine signalling and cartilage repair 

      Islam, Md Ashraful (Doctoral thesis; Doktorgradsavhandling, 2018-10-12)
      The management of articular cartilage lesions is one of the weighty challenges for orthopaedic surgeons. The use of mesenchymal stem/stromal cells (MSCs) has demonstrated as an alternative cell source for cartilage repair due to their multilineage differentiation potential and hypoimmunogenic properties. Despite the advances in cartilage repair techniques, there is no consensus relating to the most ...

    • Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation 

      Berzaghi, Rodrigo; Akhtar, Muhammad Asad; Islam, Md Ashraful; Pedersen, Brede Dille; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)
      The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...

    • Immunobiology of cancer-associated fibroblasts in the context of radiotherapy 

      Hellevik, Turid; Berzaghi, Rodrigo; Lode, Kristin; Islam, Md Ashraful; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-18)
      Radiotherapy (RT) still represents a mainstay of treatment in clinical oncology. Traditionally, the effectiveness of radiotherapy has been attributed to the killing potential of ionizing radiation (IR) over malignant cells, however, it has become clear that therapeutic efficacy of RT also involves activation of innate and adaptive anti-tumor immune responses. Therapeutic irradiation of the tumor ...

    • In vitro chondrogenic potency of surplus chondrocytes from autologous transplantation procedures does not predict short-term clinical outcomes 

      Islam, Md Ashraful; Fossum, Vegard; Hansen, Ann Kristin; Urbarova, Ilona; Knutsen, Gunnar; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)
      <p><i>Background</i>: Autologous chondrocyte implantation (ACI) has been used over the last two decades to treat focal cartilage lesions aiming to delay or prevent the onset of osteoarthritis; however, some patients do not respond adequately to the procedure. A number of biomarkers that can forecast the clinical potency of the cells have been proposed, but evidence for the relationship between in ...

    • Irradiated tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over natural killer cells 

      Yang, Nannan; Lode, Kristin; Berzaghi, Rodrigo; Islam, Md Ashraful; Martinez, Inigo Zubiavrre; Hellevik, Turid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)
      Recent studies have demonstrated that radiotherapy is able to induce anti-tumor immune responses in addition to mediating direct cytotoxic effects. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and participate actively in tumor immunoregulation. However, the capacity of CAFs to influence immune responses in the context of radiotherapy is still poorly understood. ...

    • Irradiated tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over NK cells 

      Yang, Nannan; Lode, Kristin; Berzaghi, Rodrigo; Islam, Md Ashraful; Martinez, Inigo Zubiavrre; Hellevik, Turid (Journal article; Tidsskriftartikkel, 2021-01-22)
      Recent studies have demonstrated that radiotherapy is able to induce anti-tumor immune responses in addition to mediating direct cytotoxic effects. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and participate actively in tumor immunoregulation. However, the capacity of CAFs to influence immune responses in the context of radiotherapy is still poorly understood. ...

    • Large-scale secretome analyses unveil the superior immunosuppresive phenotype of umbilical cord stromal cells as compared to other adult mesenchymal stromal cells 

      Islam, Md Ashraful; Urbarova, Ilona; Bruun, Jack-Ansgar; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-20)
      Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about the divergence of these signalling molecules in different MSC populations. The present study investigated ...

    • Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures 

      Islam, Md Ashraful; Hansen, Ann Kristin; Mennan, Claire; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-27)
      Many researchers world over are currently investigating the suitability of stromal cells harvested from foetal tissues for allogeneic cell transplantation therapies or for tissue engineering purposes. In this study, we have investigated the chondrogenic potential of mesenchymal stromal cells (MSCs) isolated from whole sections of human umbilical cord or mixed cord (UCSCs-MC), and compared them with ...

    • Nanobodies as in vivo, non-invasive, imaging agents 

      Harmand, Thibault; Islam, Md Ashraful; Pishesha, Novalia; Ploegh, Hidde L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-08)
      In vivo imaging has become in recent years an incredible tool to study biological events and has found critical applications in diagnostic medicine. Although a lot of efforts and applications have been achieved using monoclonal antibodies, other types of delivery agents are being developed. Among them, VHHs, antigen binding fragments derived from camelid heavy chain–only antibodies, also known as ...

    • Secretion rates and protein composition of extracellular vesicles released by cancer-associated fibroblasts after radiation 

      Berzaghi, Rodrigo; Islam, Md Ashraful; Hellevik, Turid; Martinez-Zubiaurre, Inigo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-24)
      Reciprocal communication between the malignant and non-malignant cellular elements in tumors is essential for cancer sustainability and plays an important role in the response of cancers to treatments. Some of this cellular crosstalk takes place via secretion of vesicles that are actively released into the extracellular space by most cell types in tumors. Recent studies have demonstrated radiation-induced ...